منابع مشابه
Nuclear Receptors: Lonesome orphans
Nuclear receptors typically bind to DNA as homodimers or heterodimers, but increasing numbers of orphan receptors have been identified that bind DNA as monomers.
متن کاملTherapeutic orphans: European perspective.
There are several factors to be considered when facing the problem of therapeutic orphans. First, there is the scientific one. We are all convinced that there is much need for more data concerning the use of drugs in children, infants, and neonates. Second, there is a regulatory factor involving political and technical institutions. Finally, we have to consider the economic interest of the phar...
متن کاملEditorial Comment: Therapeutic Orphans
By an odd and unfortunate twist of fate, infants and children are becoming “therapeutic or pharmaceutical orphans.”1 Since 1962 they have been denied the use of many new drugs. The Drug Laws of 1962 had their inception following a pediatric tragedy—the thalidomide catastrophe. The laws of 1938 followed another which resulted from the use of a pediatric dosage form, “elixir” of sulfanilamide. By...
متن کاملOrphans in Africa
“In at least one important dimension — school enrollment — orphans are signifi cantly disadvantaged... Although poorer children in Africa are less likely to attend school, the lower enrollment of orphans is not accounted for solely by their lower wealth. Instead, our results suggest that the special disadvantage orphans face is primarily due to their living arrangements. Across a large number o...
متن کاملFewer orphans than previously thought?
The editors of IJE have commented on the surprising number of papers in their journal and other journals that fail to be cited even once. According to their most recent calculations, 17% of papers in IJE and 40% of those in Epidemiology achieve no recognition in the scientific literature. These numbers do not seem very plausible, so I decided to check. Using the most recent data available from ...
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ژورنال
عنوان ژورنال: Addiction
سال: 2011
ISSN: 0965-2140
DOI: 10.1111/j.1360-0443.2010.03341.x